It refers to the recombinant vaccines in which the DNA is
used as a vaccine. The gene responsible for the immunogenic protein is
identified, isolated and cloned with corresponding expression vector. Upon introduction
into the individuals to be immunized, it produces a recombinant DNA. This DNA
when expressed triggers an immune response and the person becomes successfully
vaccinated. The mode of delivery of DNA vaccines include: direct injection into
muscle; use of vectors like adenovirus, retrovirus etc; invitro transfer of the
gene into autologous cells and reimplantation of the same and particle gun
delivery of the DNA.
In certain cases, the responsible gene is integrated into live vectors which are introduced into individuals as vaccines. This is known as live recombinant vaccines. Eg: vaccinia virus. Live vaccinia virus vaccine (VV vaccine) with genes corresponding to several diseases, when introduced into the body elicit an immune response but does not actually cause the diseases
In certain cases, the responsible gene is integrated into live vectors which are introduced into individuals as vaccines. This is known as live recombinant vaccines. Eg: vaccinia virus. Live vaccinia virus vaccine (VV vaccine) with genes corresponding to several diseases, when introduced into the body elicit an immune response but does not actually cause the diseases
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